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. 1998 Aug;70(2):207-13.
doi: 10.1016/s0015-0282(98)00177-0.

Efficacy of treatment for unexplained infertility

D S Guzick  1 , M W Sullivan, G D Adamson, M I Cedars, R J Falk, E P Peterson, M P Steinkampf
Affiliations
Free article

Efficacy of treatment for unexplained infertility

D S Guzick et al. Fertil Steril. 1998 Aug.
Free article

Abstract

Objective: To analyze the efficacy and cost-effectiveness of alternative treatments for unexplained infertility.

Design: Retrospective analysis of 45 published reports.

Setting: Clinical practices.

Patient(s): Couples who met criteria for unexplained infertility. Women with Stage I or Stage II endometriosis were included.

Intervention(s): Observation; clomiphene citrate (CC); gonadotropins (hMG); IUI; and GIFT and IVF.

Main outcome measure(s): Clinical pregnancy rate.

Result(s): Combined pregnancy rates per initiated cycle, adjusted for study quality, were as follows: no treatment = 1.3%-4.1%; IUI = 3.8%; CC = 5.6%; CC + IUI = 8.3%; hMG = 7.7%; hMG + IUI = 17.1%; IVF = 20.7%; GIFT = 27.0%. The estimated cost per pregnancy was $10,000 for CC + IUI, $17,000 for hMG + IUI, and $50,000 for IVF.

Conclusion(s): Clomiphene citrate + IUI is a cost-effective treatment for unexplained infertility. If this treatment fails, hMG + IUI and assisted reproduction are efficacious therapeutic options.

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