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. 1998 Sep;72(9):7664-8.
doi: 10.1128/JVI.72.9.7664-7668.1998.

Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy

G Zehender  1 , L Meroni, S Varchetta, C De Maddalena, B Cavalli, M Gianotto, A B Bosisio, C Colasante, G Rizzardini, M Moroni, M Galli
Affiliations

Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy

G Zehender et al. J Virol. 1998 Sep.

Abstract

We investigated the presence of human T-lymphotropic virus type 2 (HTLV-2) DNA in the peripheral blood mononuclear cell subsets obtained from 18 patients coinfected with human immunodeficiency virus type 1 and HTLV-2, 6 of whom also had predominantly sensory polyneuropathy (PSP). HTLV-2 DNA and RNA were found in CD8- and CD19-positive cells, and, for patients with PSP, in CD14-positive cells as well. Furthermore, the patients with PSP had higher proviral loads than those without PSP.

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Figures

FIG. 1
FIG. 1
Correlation between copies of HTLV-2 tax present in 10 μl of solution and LD-PCR titer.
FIG. 2
FIG. 2
Mean HTLV-2 DNA titers in different PBMC subsets in patients with PSP (dark bars) or without PSP (light bars).
See this image and copyright information in PMC

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