Review
doi: 10.1016/s0968-0004(98)01216-x.
Getting knotted: a model for the structure and activation of Spätzle
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- PMID: 9697410
- DOI: 10.1016/s0968-0004(98)01216-x
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Review
Getting knotted: a model for the structure and activation of Spätzle
Trends Biochem Sci.
1998 Jul.
Erratum in
- Trends Biochem Sci 1998 Sep;23(9):361
Abstract
Sequence analyses show that Spätzle, the Drosophila melanogaster Toll-receptor ligand, shows striking similarity to nerve growth factor and coagulogen. Comparative modelling suggests that Spätzle adopts a cystine-knot fold and forms a dimer that contains a single, intermolecular disulphide bridge. Proteolytically cleaved Spätzle could therefore dimerize and activate the Toll receptor by inducing receptor dimerization.
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