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. 1998 Jul;113(1):100-4.
doi: 10.1046/j.1365-2249.1998.00620.x.

Humoral immune response to mycobacterial heat shock protein (hsp)65 in the cerebrospinal fluid of neuro-Behçet patients

B Taşçi  1 , H Direskeneli, P Serdaroglu, G Akman-Demir, M Eraksoy, G Saruhan-Direskeneli
Affiliations

Humoral immune response to mycobacterial heat shock protein (hsp)65 in the cerebrospinal fluid of neuro-Behçet patients

B Taşçi et al. Clin Exp Immunol. 1998 Jul.

Abstract

Although systemic immune reactivity to 65-kD mycobacterial hsp65 (m-hsp65) has been shown previously in Behçet's disease (BD), local immune response was not investigated. We studied anti-m-hsp65 IgG, IgM and IgA antibodies in the serum and cerebrospinal fluid (CSF) of 25 BD patients with cerebral parenchymal involvement (p-NBD), seven BD patients with intracranial hypertension (ih-NBD), eight BD patients without central nervous system (CNS) involvement, 30 patients with multiple sclerosis (MS) and 24 patients with non-inflammatory CNS disorders (NIC). Significantly higher CSF IgG responses were detected in p-NBD patients (ELISA ratio 1.3 +/- 0.9) compared with NIC (0.7 +/- 0.4, P < 0.01). In p-NBD patients' IgG, IgM or IgA CSF anti-m-hsp65 positivity rate was 48% (12/25); this was significantly higher when compared with MS (3/30; P < 0.03) and NIC (3/24; P < 0.01). CSF anti-m-hsp65 IgG ratios correlated with the duration of BD (r = 0.4, P < 0.04) but not with the duration of neurological involvement. Serum IgM and IgA responses were elevated in ih-NBD, suggesting a different type of involvement than p-NBD. These results implicate an increased local humoral response to m-hsp65 in the CSF of p-NBD patients, which might be related to the pathogenesis of neurological involvement.

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Figures

Fig. 1
Fig. 1
Anti-mycobacterial hsp65 (m-hsp65) IgG responses detected in the cerebrospinal fluid (CSF) of the patient groups. NIC, Non-inflammatory controls; p-NBD, neuro-Behçet's disease with parenchymal involvement; ih-NBD, neuro-Behçet's disease with intracranial hypertension; c-BD, Behçet's disease without neurological involvement; MS, multiple sclerosis. Horizontal lines indicate the mean value of each group.
Fig. 2
Fig. 2
Anti-mycobacterial hsp65 (m-hsp65) IgM responses detected in the cerebrospinal fluid (CSF) of the patient groups. NIC, Non-inflammatory controls; p-NBD, neuro-Behçet's disease with parenchymal involvement; ih-NBD, neuro-Behçet's disease with intracranial hypertension; c-BD, Behçet's disease without neurological involvement; MS, multiple sclerosis. Horizontal lines indicate the mean value of each group.
Fig. 3
Fig. 3
Anti-mycobacterial hsp65 (m-hsp65) IgA responses detected in the cerebrospinal fluid (CSF) of the patient groups. NIC, non-inflammatory controls; p-NBD, neuro-Behçet's disease with parenchymal involvement; ih-NBD, neuro-Behçet's disease with intracranial hypertension; c-BD, Behçet's disease without neurological involvement; MS, multiple sclerosis. Horizontal lines indicate the mean value of each group.
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