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. 1998 Jan-Feb;116(1):1625-8.
doi: 10.1590/s1516-31801998000100006.

Langerhans cell histiocytosis

M de L Chauffaille  1 , R M Valério, C M Diniz, M M Simões, S Enokihara, N Michalany, K V Ferreira, J A Martinez, K M Hassun, A N Atallah, J Kerbauy
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Free article

Langerhans cell histiocytosis

M de L Chauffaille et al. Sao Paulo Med J. 1998 Jan-Feb.
Free article

Abstract

The authors present a rare case of Langerhans cell histiocytosis in a 31 year old female patient with vulvar, peri-anal and oral lesions, diabetes insipidus, pulmonary skin and bone infiltrations. Skin biopsy immunohistochemistry presented positive S100 protein and vimentin, but the diagnosis was done with the demonstration of Birbeck granules with electronic microscopy. The treatment was based on systematical chemotherapy although vulvar lesion has a bad response to chemotherapy.

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