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. 1998 Aug;39(8):893-6.
doi: 10.1111/j.1528-1157.1998.tb01187.x.

Epilepsy in patients with multiple sclerosis: radiological-clinical correlations

T Moreau  1 , D Sochurkova, M Lemesle, G Madinier, T Billiar, M Giroud, R Dumas
Affiliations

Epilepsy in patients with multiple sclerosis: radiological-clinical correlations

T Moreau et al. Epilepsia. 1998 Aug.

Abstract

Purpose: To determine potential mechanisms of epilepsy in patients with multiple sclerosis (MS).

Methods: Among 402 patients with clinically and radiologically defined MS, including de novo cases, presenting to the Neurology Service, University Hospital of Dijon, we identified 17 with epileptic seizures (4.25%). Among them, the percentage with partial seizures (50%) was greater than that in the reference population.

Results: In most of the patients with MS, plaques were localized in the frontal region, associated with frontal and callosal atrophy, a frontal syndrome, and severe disability status (as assessed by a standard scale). Magnetic resonance imaging (MRI) showed numerous subcortical plaques. Seizures generally were well controlled with antiepileptic drugs (AEDs).

Conclusions: Our data suggest that the subcortical plaques of MS underlie seizure activity in patients with MS and epilepsy.

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