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. 1976 Sep;6(5):613-7.
doi: 10.1007/BF01971579.

Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs

E Arrigoni-Martelli, E Bramm, E C Huskisson, D A Willoughby, P A Dieppe

Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs

E Arrigoni-Martelli et al. Agents Actions. 1976 Sep.

Abstract

A delayed hypersensitivity response was induced in the rat paw using pertussis vaccine. Oedema was measured after the challenging injection. D-penicillamine and levamisole enhanced the response, while indomethacin suppressed it. This model is useful to distinguish the effects of anti-inflammatory drugs from those like D-Penicillamine which have a specific activity in rheumatoid arthritis.

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