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Review
. 1998 Jul;43(7):1931-5.
doi: 10.1088/0031-9155/43/7/014.

Pharmaceutical applications of in vivo EPR

K Mäder  1
Affiliations
Review

Pharmaceutical applications of in vivo EPR

K Mäder. Phys Med Biol. 1998 Jul.

Abstract

The aim of this article is to discuss the applications of in vivo EPR in the field of pharmacy. In addition to direct detection of free radical metabolites and measurement of oxygen, EPR can be used to characterize the mechanisms of drug release from biodegradable polymers. Unique information about drug concentration, the microenvironment (viscosity, polarity, pH) and biodistribution (by localized measurement or EPR Imaging) can be obtained.

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