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. 1998 Aug 15;317(7156):433-7.
doi: 10.1136/bmj.317.7156.433.

Infection with HIV and hepatitis C virus among injecting drug users in a prevention setting: retrospective cohort study

I van Beek  1 , R Dwyer, G J Dore, K Luo, J M Kaldor
Affiliations

Infection with HIV and hepatitis C virus among injecting drug users in a prevention setting: retrospective cohort study

I van Beek et al. BMJ. .

Abstract

Objectives: To estimate the incidence of HIV and hepatitis C virus and risk factors for seroconversion among a cohort of injecting drug users.

Design: Retrospective cohort study.

Setting: Primary healthcare facility in central Sydney.

Subjects: Injecting drug users tested for HIV-1 antibody (n=1179) and antibodies to hepatitis C virus (n=1078) from February 1992 to October 1995.

Main outcome measures: Incidence of HIV-1 and hepatitis C virus among seronegative subjects who injected drugs and underwent repeat testing. Demographic and behavioural risk factors for hepatitis seroconversion.

Results: Incidence of HIV-1 among 426 initially seronegative injecting drug users was 0.17/100 person years (two seroconversions) compared with an incidence of hepatitis C virus of 20.9/100 person years (31 seroconversions) among 152 injecting drug users initially negative for hepatitis C virus. Incidence of hepatitis C virus among injecting drug users aged less than 20 years was 75.6/100 person years. Independent risk factors for hepatitis C virus seroconversion were age less than 20 years and a history of imprisonment.

Conclusions: In a setting where prevention measures have contributed to the maintenance of low prevalence and incidence of HIV-1, transmission of hepatitis C virus continues at extremely high levels, particularly among young injecting drug users.

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References

    1. Crofts N, Hopper JL, Bowden SD, Breschkin AM, Milner R, Locarnini SA. Hepatitis C virus among a cohort of Victorian injecting drug users. Med J Aust. 1993;159:237–241. - PubMed
    1. Patti AM, Santi AL, Pompa MG, Giustini C, Vescia N, Mastroeni I, et al. Viral hepatitis and drugs: a continuing problem. Int J Epidemiol. 1993;22:135–159. - PubMed
    1. Van Beek I, Buckley R. Stewart M, MacDonald M, Kaldorisk factors for hepatitis C virus infection among injecting drug users in Sydney. Genitourin Med. 1994;70:321–324. - PMC - PubMed
    1. Love A, Stanzeit B. Hepatitis C virus infection in Iceland: a recently introduced blood-borne disease. Epidemiol Infection. 1994;113:529–536. - PMC - PubMed
    1. Crofts N, Stewart T, Hearne P, Ping XY, Breschkin AM, Locarnini SA. Spread of blood borne viruses among Australian prison entrants. BMJ. 1995;310:285–288. - PMC - PubMed

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