This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Review

. 1998 Aug 18;95(17):9713-5.

doi: 10.1073/pnas.95.17.9713.

Influenza virus hemagglutinin cleavage into HA1, HA2: no laughing matter

J K Taubenberger¹

Affiliations

Affiliation

¹ Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA. taubenbe@afip.osd.mil

PMID: 9707539
PMCID: PMC33880
DOI: 10.1073/pnas.95.17.9713

Review

Influenza virus hemagglutinin cleavage into HA1, HA2: no laughing matter

J K Taubenberger. Proc Natl Acad Sci U S A. 1998.

. 1998 Aug 18;95(17):9713-5.

doi: 10.1073/pnas.95.17.9713.

Author

J K Taubenberger¹

Affiliation

¹ Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA. taubenbe@afip.osd.mil

PMID: 9707539
PMCID: PMC33880
DOI: 10.1073/pnas.95.17.9713

No abstract available

PubMed Disclaimer

Comment on

A novel mechanism for the acquisition of virulence by a human influenza A virus.
Goto H, Kawaoka Y. Goto H, et al. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10224-8. doi: 10.1073/pnas.95.17.10224. Proc Natl Acad Sci U S A. 1998. PMID: 9707628 Free PMC article.

Similar articles

Vaccine-induced anti-HA2 antibodies promote virus fusion and enhance influenza virus respiratory disease.
Khurana S, Loving CL, Manischewitz J, King LR, Gauger PC, Henningson J, Vincent AL, Golding H. Khurana S, et al. Sci Transl Med. 2013 Aug 28;5(200):200ra114. doi: 10.1126/scitranslmed.3006366. Sci Transl Med. 2013. PMID: 23986398
D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice.
Zheng B, Chan KH, Zhang AJ, Zhou J, Chan CC, Poon VK, Zhang K, Leung VH, Jin DY, Woo PC, Chan JF, To KK, Chen H, Yuen KY. Zheng B, et al. Exp Biol Med (Maywood). 2010 Aug;235(8):981-8. doi: 10.1258/ebm.2010.010071. Exp Biol Med (Maywood). 2010. PMID: 20660098
Intermonomer Interactions in Hemagglutinin Subunits HA1 and HA2 Affecting Hemagglutinin Stability and Influenza Virus Infectivity.
Wang W, DeFeo CJ, Alvarado-Facundo E, Vassell R, Weiss CD. Wang W, et al. J Virol. 2015 Oct;89(20):10602-11. doi: 10.1128/JVI.00939-15. Epub 2015 Aug 12. J Virol. 2015. PMID: 26269180 Free PMC article.
Influenza virus: a master of metamorphosis.
De Jong JC, Rimmelzwaan GF, Fouchier RA, Osterhaus AD. De Jong JC, et al. J Infect. 2000 May;40(3):218-28. doi: 10.1053/jinf.2000.0652. J Infect. 2000. PMID: 10908015 Review.
The pathogenesis of influenza in humans.
Zambon MC. Zambon MC. Rev Med Virol. 2001 Jul-Aug;11(4):227-41. doi: 10.1002/rmv.319. Rev Med Virol. 2001. PMID: 11479929 Review.

See all similar articles

Cited by

Novel insights into proteolytic cleavage of influenza virus hemagglutinin.
Bertram S, Glowacka I, Steffen I, Kühl A, Pöhlmann S. Bertram S, et al. Rev Med Virol. 2010 Sep;20(5):298-310. doi: 10.1002/rmv.657. Rev Med Virol. 2010. PMID: 20629046 Free PMC article. Review.
Unique features of a recombinant haemagglutinin influenza vaccine that influence vaccine performance.
Arunachalam AB, Post P, Rudin D. Arunachalam AB, et al. NPJ Vaccines. 2021 Dec 2;6(1):144. doi: 10.1038/s41541-021-00403-7. NPJ Vaccines. 2021. PMID: 34857771 Free PMC article. Review.
Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics.
Zhang Y, Lin X, Zhang F, Wu J, Tan W, Bi S, Zhou J, Shu Y, Wang Y. Zhang Y, et al. Biochem Biophys Res Commun. 2009 Sep 18;387(2):405-8. doi: 10.1016/j.bbrc.2009.07.040. Epub 2009 Jul 15. Biochem Biophys Res Commun. 2009. PMID: 19615337 Free PMC article.
A risk marker of tribasic hemagglutinin cleavage site in influenza A (H9N2) virus.
Zhang J, Ma K, Li B, Chen Y, Qiu Z, Xing J, Huang J, Hu C, Huang Y, Li H, Liu D, Liao M, Qi W. Zhang J, et al. Commun Biol. 2021 Jan 15;4(1):71. doi: 10.1038/s42003-020-01589-7. Commun Biol. 2021. PMID: 33452423 Free PMC article.
Positive selection on hemagglutinin and neuraminidase genes of H1N1 influenza viruses.
Li W, Shi W, Qiao H, Ho SY, Luo A, Zhang Y, Zhu C. Li W, et al. Virol J. 2011 Apr 21;8:183. doi: 10.1186/1743-422X-8-183. Virol J. 2011. PMID: 21507270 Free PMC article.

See all "Cited by" articles

References

1. Goto H, Kawaoka Y. Proc Natl Acad Sci USA. 1998;95:10224–10228. - PMC - PubMed
1. Lazarowitz S G, Goldberg A R, Choppin P W. Virology. 1973;56:172–180. - PubMed
1. Schulman J L, Palese P. J Virol. 1977;24:170–176. - PMC - PubMed
1. Li S, Schulman J, Itamura S, Palese P. J Virol. 1993;67:6667–6673. - PMC - PubMed
1. Lamb R A, Krug R M. In: Fields Virology. 3rd Ed. Fields B N, Knipe D M, Howley P M, editors. Philadelphia: Lippincott-Raven; 1996. pp. 1359–1362.

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Research Materials
- NCI CPTC Antibody Characterization Program
Miscellaneous
- NCI CPTAC Assay Portal