Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 May;51(5):396-8.
doi: 10.1136/jcp.51.5.396.

Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT)

K Kobayashi  1 , K Yokota, T Yoshino, Y Kawahara, A Dey, Y Hirai, K Oguma, T Akagi
Affiliations

Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT)

K Kobayashi et al. J Clin Pathol. 1998 May.

Abstract

Aims: To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma.

Methods: Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2).

Results: Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted.

Conclusions: Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.

PubMed Disclaimer

References

    1. Histopathology. 1987 May;11(5):445-62 - PubMed
    1. Gastroenterology. 1996 Sep;111(3):655-65 - PubMed
    1. Am J Gastroenterol. 1991 Aug;86(8):976-80 - PubMed
    1. Lancet. 1991 Nov 9;338(8776):1175-6 - PubMed
    1. Immunol Today. 1992 Jan;13(1):17-21 - PubMed

Publication types

MeSH terms