doi: 10.1080/07328319808005178.
Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein
Affiliations
- PMID: 9708352
- PMCID: PMC2556045
- DOI: 10.1080/07328319808005178
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Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein
Nucleosides Nucleotides.
1998 Jan-Mar.
Abstract
The design and synthesis of analogues of diadenosine 5',5"'-P1,P3-triphosphate that are resistant to pyrophosphate hydrolysis is described in relation to their rôle in signalling and tumorigenesis involving the Fhit protein, the human fragile histidine triad protein, which is a novel Ap3A binding/cleaving protein.
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References
-
- McLennan AG.Ap4A and other dinucleoside polyphosphates 1992CRC Press; Boca Raton: FD 33431
-
- Finamore FJ, Warner AH. J. Biol. Chem. 1963;238:344–348. - PubMed
-
- Zamecnik PC, Stephenson ML, Janeway CM, Randerath K. Biochem. Biophys. Res. Commun. 1966;24:91–97. - PubMed
-
- Kitzler JW, Farr SB, Ames BN. in Ref.1, 135–149.
-
- Lüthje J, Ogilvie A. Biochem. Biophys. Res. Commun. 1983;115:253–260. - PubMed
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