Time for emergency contraception with levonorgestrel alone
- PMID: 9708743
- DOI: 10.1016/S0140-6736(98)22032-0
Time for emergency contraception with levonorgestrel alone
Erratum in
- Lancet 1998 Aug 22;352(9128):658
- Lancet. 2005 Jul 23-29;366(9482):292
Abstract
PIP: The World Health Organization (WHO) multicenter, randomized trial reported in this issue of "The Lancet" confirms that levonorgestrel-only (two 750-mcg doses) is significantly more effective in preventing pregnancy after unprotected intercourse than the standard Yuzpe regimen (two doses of 500 mcg levonorgestrel and 100 mcg ethinyl estradiol) and is further associated with significantly less nausea and vomiting. When initiated within 24 hours of coitus, the failure rate was only 0.4% for levonorgestrel compared with 2.0% for the combined hormonal method. A further advantage of a progestogen-only emergency contraceptive method is avoidance of contraindications in women with past proven arterial or venous thrombosis or a current attack of migraine with focal aura. Although only one pharmaceutical company (Gedeon Richter in Budapest, Hungary) currently manufactures 750 mcg of levonorgestrel in a single tablet, others are likely to follow this example given the findings of the WHO study. Strong pressure exists to increase availability of postcoital contraception through trained nurses and retail pharmacists. However, potential users will still require counseling on the importance of selecting a long-term method of contraception and a family planning provider.
Comment in
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Emergency contraception: WHO Task Force study.Lancet. 1998 Oct 10;352(9135):1223. doi: 10.1016/S0140-6736(05)60562-4. Lancet. 1998. PMID: 9777863 No abstract available.
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Emergency contraception.Lancet. 1998 Oct 31;352(9138):1477. doi: 10.1016/S0140-6736(05)61309-8. Lancet. 1998. PMID: 9808025 No abstract available.
Comment on
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Randomised controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Task Force on Postovulatory Methods of Fertility Regulation.Lancet. 1998 Aug 8;352(9126):428-33. Lancet. 1998. PMID: 9708750 Clinical Trial.
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