Chronic L-deprenyl treatment alters brain monoamine levels and reduces impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder
- PMID: 9708846
- DOI: 10.1016/s0166-4328(97)00176-9
Chronic L-deprenyl treatment alters brain monoamine levels and reduces impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder
Abstract
Effects of chronic L-deprenyl administration on hyperactive behaviour and brain monoamine levels were studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. SHR were hyperactive, impulsive and had impaired sustained attention when tested with a multiple 2-min fixed interval (FI) 5-min extinction (EXT) schedule of reinforcement. Even low, 0.25 mg/kg, doses of chronically-administered L-deprenyl reduced the impulsiveness (bursts of responses with short interresponse times) of SHR, without altering the general hyperactivity or the impaired sustained attention. The drug had no effect on WKY behaviour. The levels of noradrenaline (NA), dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and their metabolites, measured in neostriatum, nucleus accumbens and frontal cortex, showed that L-deprenyl effectively inhibited monoamine oxidase (MAO) activity. These results suggest that impulsiveness is a behavioural component that may be operating independent of the other components, like hyperactivity and deficient sustained attention, and that can be reduced by chronic MAO-B inhibition with L-deprenyl in this strain of rats. The positive effect of L-deprenyl on impulsiveness is discussed as due either to normalization of an asymmetric dopaminergic activity in the nucleus accumbens, or to a restoration of normal DA function in the prefrontal cortex.
Similar articles
-
Alpha 2-adrenoceptor mediated inhibition of [3H]dopamine release from nucleus accumbens slices and monoamine levels in a rat model for attention-deficit hyperactivity disorder.Neurochem Res. 1995 Apr;20(4):427-33. doi: 10.1007/BF00973098. Neurochem Res. 1995. PMID: 7651580
-
Altered dopaminergic function in the prefrontal cortex, nucleus accumbens and caudate-putamen of an animal model of attention-deficit hyperactivity disorder--the spontaneously hypertensive rat.Brain Res. 1995 Apr 10;676(2):343-51. doi: 10.1016/0006-8993(95)00135-d. Brain Res. 1995. PMID: 7614004
-
In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl.Biochem Pharmacol. 1995 Jun 29;50(1):97-102. doi: 10.1016/0006-2952(95)00022-r. Biochem Pharmacol. 1995. PMID: 7605351
-
The spontaneously hypertensive-rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations.Neurosci Biobehav Rev. 2003 Nov;27(7):639-51. doi: 10.1016/j.neubiorev.2003.08.007. Neurosci Biobehav Rev. 2003. PMID: 14624808 Review.
-
Hypodopaminergic and hypernoradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder--the spontaneously hypertensive rat.Behav Brain Res. 2002 Mar 10;130(1-2):191-6. doi: 10.1016/s0166-4328(01)00425-9. Behav Brain Res. 2002. PMID: 11864734 Review.
Cited by
-
DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics.Pharmgenomics Pers Med. 2010;3:61-78. doi: 10.2147/pgpm.s6800. Epub 2010 May 21. Pharmgenomics Pers Med. 2010. PMID: 23226043 Free PMC article.
-
Effect of acute swim stress on plasma corticosterone and brain monoamine levels in bidirectionally selected DxH recombinant inbred mouse strains differing in fear recall and extinction.Stress. 2014 Dec;17(6):471-83. doi: 10.3109/10253890.2014.954104. Stress. 2014. PMID: 25117886 Free PMC article.
-
Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition.J Neurosci. 2001 Jan 1;21(1):35-44. doi: 10.1523/JNEUROSCI.21-01-00035.2001. J Neurosci. 2001. PMID: 11150317 Free PMC article.
-
H3 receptor blockade by thioperamide enhances cognition in rats without inducing locomotor sensitization.Psychopharmacology (Berl). 2003 Jun;167(4):363-72. doi: 10.1007/s00213-003-1431-0. Epub 2003 Apr 8. Psychopharmacology (Berl). 2003. PMID: 12682709
-
An updated review on animal models to study attention-deficit hyperactivity disorder.Transl Psychiatry. 2024 Apr 11;14(1):187. doi: 10.1038/s41398-024-02893-0. Transl Psychiatry. 2024. PMID: 38605002 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical