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Clinical Trial
. 1998 Aug;133(2):275-8.
doi: 10.1016/s0022-3476(98)70235-5.

Combined schedule of 7-valent pneumococcal conjugate vaccine followed by 23-valent pneumococcal vaccine in children and young adults with sickle cell disease

L Vernacchio  1 , E J Neufeld, K MacDonald, S Kurth, S Murakami, C Hohne, M King, D Molrine
Affiliations
Clinical Trial

Combined schedule of 7-valent pneumococcal conjugate vaccine followed by 23-valent pneumococcal vaccine in children and young adults with sickle cell disease

L Vernacchio et al. J Pediatr. 1998 Aug.

Abstract

We compared the immunogenicity of 7-valent pneumococcal-conjugate vaccine plus 23-valent pneumococcal vaccine to immunization with 23-valent vaccine only in individuals > or = 2 years of age with sickle cell disease. IgG pneumococcal antibody concentrations were higher in the combined schedule group with no increase in side effects observed after immunization with 23-valent vaccine.

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