Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas
- PMID: 9709923
- DOI: 10.1210/jcem.83.8.4888
Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas
Abstract
To investigate the role of tumor suppressor genes in sporadic pituitary adenomas, we first analyzed loss of heterozygosity on 11q13 with microsatellite analysis in 31 tumors. Loss of heterozygosity on 11q13 was detected in 1 mixed GH/PRL adenoma, and the somatic 22-bp deletion of the multiple endocrine neoplasia type 1 (MEN1) gene encoding menin was detected in this tumor. Trisomy 11 suggested by the decreased mean allelic ratios of 66% or 65% for 16 or 13 microsatellite markers, respectively, in 2 of 31 pituitary adenomas was confirmed by interphase fluorescence in situ hybridization. Screening for mutations of the MEN1 gene did not find mutations with PCR-single strand conformation polymorphism analysis in other pituitary adenomas retaining heterozygosity on 11q13. Based on these, it is concluded that inactivation of the MEN1 gene comprises a rare etiology for tumorigenesis of the pituitary gland, and that trisomy 11 or another gene(s) may contribute to the pathogenesis of sporadic pituitary adenomas.
Comment in
-
Multiple endocrine neoplasia--syndromes of the twentieth century.J Clin Endocrinol Metab. 1998 Aug;83(8):2617-20. doi: 10.1210/jcem.83.8.5045. J Clin Endocrinol Metab. 1998. PMID: 9709920 Review. No abstract available.
Similar articles
-
Screening for MEN1 tumor suppressor gene mutations in sporadic pituitary tumors.J Endocrinol Invest. 2000 May;23(5):304-9. doi: 10.1007/BF03343727. J Endocrinol Invest. 2000. PMID: 10882148
-
Tumor suppressor loss in pituitary tumors.Brain Pathol. 2001 Jul;11(3):342-55. doi: 10.1111/j.1750-3639.2001.tb00404.x. Brain Pathol. 2001. PMID: 11414476 Free PMC article. Review.
-
Analysis of the MEN1 gene in sporadic pituitary adenomas.J Pathol. 1999 Jun;188(2):168-73. doi: 10.1002/(SICI)1096-9896(199906)188:2<168::AID-PATH342>3.0.CO;2-4. J Pathol. 1999. PMID: 10398160
-
Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenoma in contrast to MEN1 in Japanese.J Clin Endocrinol Metab. 1998 Mar;83(3):960-5. doi: 10.1210/jcem.83.3.4653. J Clin Endocrinol Metab. 1998. PMID: 9506756
-
[Familial pituitary tumors].Nihon Rinsho. 1995 Nov;53(11):2691-6. Nihon Rinsho. 1995. PMID: 8538028 Review. Japanese.
Cited by
-
The genomic and transcriptomic landscape of a HeLa cell line.G3 (Bethesda). 2013 Aug 7;3(8):1213-24. doi: 10.1534/g3.113.005777. G3 (Bethesda). 2013. PMID: 23550136 Free PMC article.
-
Examination of the relationship between chromosome abnormality in pituitary adenomas and tumor invasiveness by normal karyotype analysis and interphase fluorescence staining.Med Oncol. 2012 Dec;29(5):3462-6. doi: 10.1007/s12032-012-0296-7. Epub 2012 Jul 7. Med Oncol. 2012. PMID: 22772969
-
Isolated familial somatotropinoma.Pituitary. 2004;7(2):95-101. doi: 10.1007/s11102-005-0-04-0. Pituitary. 2004. PMID: 15761658
-
Screening for MEN1 tumor suppressor gene mutations in sporadic pituitary tumors.J Endocrinol Invest. 2000 May;23(5):304-9. doi: 10.1007/BF03343727. J Endocrinol Invest. 2000. PMID: 10882148
-
Tumor suppressor loss in pituitary tumors.Brain Pathol. 2001 Jul;11(3):342-55. doi: 10.1111/j.1750-3639.2001.tb00404.x. Brain Pathol. 2001. PMID: 11414476 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical