Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Sep;66(9):4522-5.
doi: 10.1128/IAI.66.9.4522-4525.1998.

Elevated concentrations of eotaxin and interleukin-5 in human neurocysticercosis

C A Evans  1 , H H Garcia, A Hartnell, R H Gilman, P J Jose, M Martinez, D G Remick, T J Williams, J S Friedland
Affiliations

Elevated concentrations of eotaxin and interleukin-5 in human neurocysticercosis

C A Evans et al. Infect Immun. 1998 Sep.

Abstract

Symptomatic neurocysticercosis, a major cause of epilepsy worldwide, results from inflammation around Taenia solium larvae, but the mechanisms are unknown. Eotaxin, not previously reported in cases of human infection, and interleukin-5 (IL-5) but not IL-8 concentrations were elevated in patient serum, and IL-5 levels were also elevated in cerebrospinal fluid (CSF). Eosinophil-selective mediators may be involved in the pathogenesis of cysticercosis. IL-6 concentrations were also elevated in patient CSF, possibly indicative of an acute-phase response.

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
Concentrations of eotaxin (a), IL-5 (b), and IL-8 (c) in serum and CSF of neurocysticercosis patients (•) and control subjects (○). Geometric means of immunoreactive cytokine concentrations are indicated by “X.” Only statistically significant differences between groups are shown.
FIG. 2
FIG. 2
Concentrations of the proinflammatory cytokines TNF-α (a) and IL-6 (b) in serum and CSF of neurocysticercosis patients (•) and control subjects (○). Geometric means of bioactive cytokine concentrations are indicated by “X.” Only statistically significant differences between groups are shown.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ali-Khan Z, Siboo R, Meerovitch E, Faubert G, Faucher M G. Cysticercosis racemosus in an eosinophilic phlegmon in the brain. Trans R Soc Trop Med Hyg. 1981;75:774–779. - PubMed
    1. Aloisi F, Care A, Borsellino G, Gallo P, Rosa S, Bassani A, Cabibbo A, Testa U, Levi G, Peschle C. Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha. J Immunol. 1992;149:2358–2366. - PubMed
    1. Amiri P, Locksley R M, Parslow T G, Sadick M, Rector E, Ritter D, McKerrow J H. Tumour necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature. 1992;356:604–607. - PubMed
    1. Collins P D, Marleau S, Griffiths-Johnson D A, Jose P J, Williams T J. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med. 1995;182:1169–1174. - PMC - PubMed
    1. DeForge L E, Remick D G. Sandwich ELISA for detection of picogram quantities of interleukin-8. Immunol Investig. 1991;20:89–97. - PubMed

Publication types

LinkOut - more resources