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. 1998 Sep;66(9):4564-7.
doi: 10.1128/IAI.66.9.4564-4567.1998.

A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection

D M Williams  1 , B G Grubbs, T Darville, K Kelly, R G Rank
Affiliations

A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection

D M Williams et al. Infect Immun. 1998 Sep.

Abstract

Interleukin-6-deficient (IL-6(-/-)) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after intranasal infection. Gamma interferon production and chlamydia-specific antibody levels were consistent with a decreased but reversible Th1-like response in IL-6(-/-) mice. IL-6 is needed for an optimal early host response to this infection.

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