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Review
. 1998 Jun;53(6):357-62.

[Myelodysplastic syndromes: preleukemic syndromes]

[Article in French]
F Tassin  1 , J P Hermanne, N Schaaf-Lafontaine, C Herens, A Thiry, J M Paulus, J Boniver, G Fillet
Affiliations
  • PMID: 9713217
Free article
Review

[Myelodysplastic syndromes: preleukemic syndromes]

[Article in French]
F Tassin et al. Rev Med Liege. 1998 Jun.
Free article

Abstract

The myelodysplastic syndromes (MDS) are a heterogeneous group of disorders characterized by peripheral blood cytopenias with a hypercellular bone marrow exhibiting dyspoiesis. The predominant in elderly patients are associated with a high risk of progression to acute myelogenous leukemia. The etiology of MDS is unknown in most cases. About 10% of MDSs are secondary. MDS are classified by the French American British (FAB) classification into five subgroups. The incidence of the disorders is difficult to estimate but it seems to be increasing. Clonal cytogenetic aberrations are found in 30 to 50% of de novo MDS. The only currative treatment for MDS is allogeneic bone marrow transplantation.

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