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. 1976 Aug;57(4):472-80.

Mouse hydrocephalus and encephalitis following intracerebral infection with Newcastle disease vaccine viruses

M Chew-Lim, H E Webb

Mouse hydrocephalus and encephalitis following intracerebral infection with Newcastle disease vaccine viruses

M Chew-Lim et al. Br J Exp Pathol. 1976 Aug.

Abstract

Hydrocephalus and encephalitis in 14-day-old mice was induced by an intracerebral inoculation of a high dose of live Newcastle disease vaccine viruses. The distended lateral ventricles occurred as a result of aqueduct stenosis superimposed on ciliary degeneration and destruction of ependymal cells. The brain virus titres were high on Days 3, 5 and 7 but never exceeded the titre of the original dose given. Positive serum haemagglutination-inhibition titres persisted throughout the experiment.

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References

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