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. 1976 Mar 22;09(5-6):439-41.
doi: 10.1007/BF00606562.

The influence of disulfiram on the half life and metabolic clearance rate of diphenylhydantoin and tolbtamide in man

T L Svendsen, M B Kristensen, J M Hansen, L Skovsted

The influence of disulfiram on the half life and metabolic clearance rate of diphenylhydantoin and tolbtamide in man

T L Svendsen et al. Eur J Clin Pharmacol. .

Abstract

Diphenylhydantoin (DPH) and tolbutamide serum levels were studied in ten volunteers before and after 4 days of disulfiram treatment. The mean DPH half life increased significantly from 11.0 +/- a.2 h to 19.0 +/- 3.3 h, and the mean DPH metabolic clearance rate decreased significantly from 51.2 +/- 17.2 ml/min to 33.9 +/- 12.0 ml/min during medication. No significant changes in the half life or metabolic clearance rate of tolbutamide was observed.

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