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Review
. 1998;43(3):275-8.
doi: 10.1007/BF02818612.

Pathogenicity island mediates Helicobacter pylori interaction with the host

R Rappuoli  1 , C Lange, S Censini, A Covacci
Affiliations
Review

Pathogenicity island mediates Helicobacter pylori interaction with the host

R Rappuoli et al. Folia Microbiol (Praha). 1998.

Abstract

In Helicobacter pylori, a pathogenicity island (PAI) of approximately 40 kb, named cag, is present in a subset of strains. The strains containing the PAI are more virulent than those that do not contain it, and are associated with peptic ulcer and gastric cancer. A putative secretory mechanism is encoded by this PAI. This secretory system is thought to be involved in the induction of the proiflammatory lymphokine IL-8 and tyrosine phosphorylation of proteins in the gastric cells. We are currently investigating the potential toxic factors exported by this region.

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References

    1. Trends Microbiol. 1996 Feb;4(2):64-8 - PubMed
    1. J Exp Med. 1994 May 1;179(5):1653-58 - PubMed
    1. J Clin Pathol. 1995 Oct;48(10):967-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7595-9 - PubMed
    1. Science. 1996 Aug 23;273(5278):1107-9 - PubMed

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