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. 1998;63(8):PL113-7.
doi: 10.1016/s0024-3205(98)00322-1.

Appetite suppression and weight loss after the cannabinoid antagonist SR 141716

G Colombo  1 , R Agabio, G Diaz, C Lobina, R Reali, G L Gessa
Affiliations

Appetite suppression and weight loss after the cannabinoid antagonist SR 141716

G Colombo et al. Life Sci. 1998.

Abstract

The effect of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716 (2.5 and 10 mg/kg; i.p.) reduced dose-dependently both food intake and body weight. Tolerance to the anorectic effect developed within 5 days; in contrast, body weight in SR 141716-treated rats remained markedly below that of vehicle-treated rats throughout the entire treatment period (14 days). The results suggest that brain cannabinoid receptors are involved in the regulation of appetite and body weight.

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