Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Aug;68(4):237-41.
doi: 10.1002/(sici)1096-9098(199808)68:4<237::aid-jso6>3.0.co;2-5.

Prognostic factors in differentiated thyroid carcinoma: a multivariate analysis of 234 consecutive patients

R Bellantone  1 , C P Lombardi, M Boscherini, A Ferrante, M Raffaelli, F Rubino, M Bossola, F Crucitti
Affiliations

Prognostic factors in differentiated thyroid carcinoma: a multivariate analysis of 234 consecutive patients

R Bellantone et al. J Surg Oncol. 1998 Aug.

Abstract

Background and objectives: The clinical characteristics and patient outcome of a group of patients treated for differentiated thyroid carcinoma (DTC) were analyzed in order to assess the relative influence of different prognostic factors.

Materials and methods: We retrospectively reviewed data about sex, age, size and histologic behavior of the tumor, extrathyroid extension of the tumor, lymph node status, distant metastasis at diagnosis, surgical procedures, and overall survival from 234 patients treated for DTC. Data were submitted to a statistical analysis.

Results: Using a univariate analysis, we found that survival rates were significantly influenced by age (P = 0.0001), size (P = 0.018), extrathyroidal extension (P = 0.000001), lymph node involvement (P = 0.03), and distant metastases (P = 0.049). Age and size were independent prognostic factors at multivariate analysis (t = 2.694 and t = 2.443, respectively).

Conclusions: On the basis of our results and of a review of the literature, we conclude that total thyroidectomy is the treatment of choice in DTC, except for small (<1 cm) papillary carcinoma, that could be treated by lobectomy plus isthmectomy, while lymphadenectomy is indicated only in case of macroscopic involvement.

PubMed Disclaimer

MeSH terms