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Review
. 1998 Aug;10(4):399-406.
doi: 10.1016/s0952-7915(98)80112-x.

Genetic basis of abnormal B cell development

M E Conley  1 , M D Cooper
Affiliations
Review

Genetic basis of abnormal B cell development

M E Conley et al. Curr Opin Immunol. 1998 Aug.

Abstract

A susceptibility gene in the MHC class III region may underlie the defective B-cell differentiation in familial IgA deficiency and common variable immunodeficiency. Mutations in Bruton's tyrosine kinase, immunoglobulin heavy chain and lambda 5/14.1 surrogate light chain loci disrupt B-cell development to cause profound antibody deficiency. Mutational, biochemical and transgenic studies offer insight into the function of these and other 'antibody deficiency genes'.

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