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Review
. 1998 Aug;10(4):444-9.
doi: 10.1016/s0952-7915(98)80119-2.

Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells

A J Zajac  1 , K Murali-Krishna, J N Blattman, R Ahmed
Affiliations
Review

Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells

A J Zajac et al. Curr Opin Immunol. 1998 Aug.

Abstract

The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.

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