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Case Reports
. 1998 Sep;105(2):128-33.
doi: 10.1016/s0165-4608(98)00027-2.

Deletion 1p in a low-grade chondrosarcoma in a patient with Ollier disease

Y Y Ozisik  1 , A M Meloni, S S Spanier, C H Bush, K L Kingsley, A A Sandberg
Affiliations
Case Reports

Deletion 1p in a low-grade chondrosarcoma in a patient with Ollier disease

Y Y Ozisik et al. Cancer Genet Cytogenet. 1998 Sep.

Abstract

Ollier disease is an uncommon, nonhereditary developmental disorder affecting enchondral ossification. Cytogenetic analysis of low-grade chondrosarcoma in a patient with Ollier disease (multiple enchondromatosis) revealed an interstitial deletion, del(1)(p11p31.2), as the only chromosome abnormality. This is the first cytogenetic study of a chondrosarcoma in a patient with Ollier disease. Such patients are at risk of developing chondrosarcoma and, because del(1p) is frequent in chondrosarcoma, it is suggested that this cytogenetic finding is associated with early chondrosarcomatous transformation.

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