Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Apr-Jun;23(2):218-22.
doi: 10.1007/BF03189343.

Amiloride pharmacokinetics in rat

G Segre  1 , D Cerretani, G Bruni, R Urso, G Giorgi
Affiliations

Amiloride pharmacokinetics in rat

G Segre et al. Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun.

Abstract

The kinetics of amiloride was investigated in plasma, urine, faeces and tissues of rats after oral (10 mg/kg) and i.v. (10 mg/kg bolus and 35 microg/h for 4-days infusion) administration. Initially the experimental data were analyzed by a multiexponential model, then a compartmental model was developed to describe the drug kinetics in plasma, urine, faeces and tissues after the i.v. bolus and the oral administration simultaneously. Aim of the model was also to predict the drug kinetics in plasma and tissues of rats after continuous i.v. infusion. The results of the prediction and the discrepancies between prediction and observed data allowed a deeper insight into the pharmacokinetics of amiloride.

PubMed Disclaimer

References

    1. Boll Soc Ital Biol Sper. 1989 Oct;65(10):939-43 - PubMed
    1. Hosp Pract. 1979 Sep;14(9):99-102, 103-10 - PubMed
    1. Clin Pharmacol Ther. 1969 Jan-Feb;10(1):50-63 - PubMed