Review
doi: 10.1089/jir.1998.18.549.
Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway
Affiliations
- PMID: 9726434
- DOI: 10.1089/jir.1998.18.549
Item in Clipboard
Review
Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway
J Interferon Cytokine Res.
1998 Aug.
Abstract
Sharing the Milstein Award with George R. Stark and Ian M. Kerr in the fall of 1997 brought this invitation to record personal reflections on our experiments concerning the mechanisms of action of interferon. Our work and that of the Kerr and Stark laboratories uncovered the Jak-Stat pathway through which signals from cell surface receptors reach genes in the cell nucleus. This review concentrates on that to which I can speak most reliably, that is, experiments done by my young colleagues at Rockefeller University.
Similar articles
-
A selective defect of IFN-gamma- but not of IFN-alpha-induced JAK/STAT pathway in a subset of U937 clones prevents the antiretroviral effect of IFN-gamma against HIV-1.J Immunol. 1999 Jan 1;162(1):323-30. J Immunol. 1999. PMID: 9886402
-
The JAK-STAT pathway: summary of initial studies and recent advances.Recent Prog Horm Res. 1996;51:391-403; discussion 403-4. Recent Prog Horm Res. 1996. PMID: 8701087 Review.
-
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.EMBO J. 1999 May 4;18(9):2480-8. doi: 10.1093/emboj/18.9.2480. EMBO J. 1999. PMID: 10228162 Free PMC article.
-
The Jak-STAT pathway stimulated by interferon gamma.Sci STKE. 2004 Nov 23;2004(260):tr8. doi: 10.1126/stke.2602004tr8. Sci STKE. 2004. PMID: 15561980
-
Cytokines and JAK-STAT signaling.Exp Cell Res. 1999 Nov 25;253(1):7-14. doi: 10.1006/excr.1999.4670. Exp Cell Res. 1999. PMID: 10579906 Review.
Cited by
-
Occludin regulates HIV-1 infection by modulation of the interferon stimulated OAS gene family.Res Sq [Preprint]. 2023 Jan 30:rs.3.rs-2501091. doi: 10.21203/rs.3.rs-2501091/v1. Res Sq. 2023. Update in: Mol Neurobiol. 2023 Sep;60(9):4966-4982. doi: 10.1007/s12035-023-03381-0. PMID: 36778388 Free PMC article. Updated. Preprint.
-
IRF and STAT Transcription Factors - From Basic Biology to Roles in Infection, Protective Immunity, and Primary Immunodeficiencies.Front Immunol. 2019 Jan 8;9:3047. doi: 10.3389/fimmu.2018.03047. eCollection 2018. Front Immunol. 2019. PMID: 30671054 Free PMC article. Review.
-
Type I interferons induce apoptosis by balancing cFLIP and caspase-8 independent of death ligands.Mol Cell Biol. 2013 Feb;33(4):800-14. doi: 10.1128/MCB.01430-12. Epub 2012 Dec 10. Mol Cell Biol. 2013. PMID: 23230268 Free PMC article.
-
STATs in cancer inflammation and immunity: a leading role for STAT3.Nat Rev Cancer. 2009 Nov;9(11):798-809. doi: 10.1038/nrc2734. Nat Rev Cancer. 2009. PMID: 19851315 Free PMC article. Review.
-
Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in hepatitis C virus replicon.Virol J. 2007 Sep 18;4:89. doi: 10.1186/1743-422X-4-89. Virol J. 2007. Retraction in: Virol J. 2025 Apr 19;22(1):110. doi: 10.1186/s12985-025-02735-5. PMID: 17877826 Free PMC article. Retracted.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
