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Comment
. 1998 Sep 4;281(5382):1502-6.
doi: 10.1126/science.281.5382.1502.

Segregation of transcription and replication sites into higher order domains

X Wei  1 , J Samarabandu, R S Devdhar, A J Siegel, R Acharya, R Berezney
Affiliations
Comment

Segregation of transcription and replication sites into higher order domains

X Wei et al. Science. .

Abstract

Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.

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Comment on

  • Duplicating a tangled genome.
    Cook P. Cook P. Science. 1998 Sep 4;281(5382):1466-7. doi: 10.1126/science.281.5382.1466. Science. 1998. PMID: 9750117 No abstract available.

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