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Clinical Trial
. 1998 Sep;164(9):657-63.
doi: 10.1080/110241598750005534.

Incidence and prevention of deep venous thrombosis occurring late after general surgery: randomised controlled study of prolonged thromboprophylaxis

I Lausen  1 , R Jensen, L N Jorgensen, M S Rasmussen, K M Lyng, M Andersen, H O Raaschou, P Wille-Jørgensen
Affiliations
Clinical Trial

Incidence and prevention of deep venous thrombosis occurring late after general surgery: randomised controlled study of prolonged thromboprophylaxis

I Lausen et al. Eur J Surg. 1998 Sep.

Abstract

Objective: To study the incidence of late deep venous thrombosis (DVT), and to evaluate a regimen of prolonged thromboprophylaxis after general surgery.

Design: Randomised, controlled, open trial, with blinded evaluation.

Setting: University hospital, Denmark.

Subjects: 176 consecutive patients undergoing major elective abdominal or non-cardiac thoracic operations, of whom 118 were eligible for evaluation.

Interventions: Thromboprophylaxis with a low-molecular-weight heparin, tinzaparin, given for four weeks (n = 58), compared with one week (control group, n = 60).

Main outcome measures: Presence of DVT established by bilateral venography four weeks after the operation.

Results: The incidence of late DVT in the control group was 6/60 (10%, 95% confidence interval (CI) 4% to 21%). In the prophylaxis group it was 3/58 (5.2%, 95% CI 1% to 14%) (p = 0.49).

Conclusion: Prolonged thromboprophylaxis had no significant effect on the incidence of DVT occurring late after general surgery.

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