Comparative Study
Regulation of the rate of beta-galactosidase synthese by the Bgs and Bgt loci in the mouse
- PMID: 97289
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Comparative Study
Regulation of the rate of beta-galactosidase synthese by the Bgs and Bgt loci in the mouse
J Biol Chem.
.
Free article
Abstract
We have developed an assay for the in vivo rate of beta-galactosidase synthesis in mouse tissues to assess the mechanism by which the Bgs and Bgt loci regulate activity levels of this enzyme. Genetically determined differences in liver and kidney beta-galactosidase content reflect equivalent differences in specific rates of enzyme synthesis. We conclude that Bgs and Bgt regulate beta-galactosidase activity by controlling the rate of synthesis of the beta-galactosidase molecule.
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