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Review
. 1998 Sep;5(5):597-603.
doi: 10.1128/CDLI.5.5.597-603.1998.

Cytokines, plasma immune activation markers, and clinically relevant surrogate markers in human immunodeficiency virus infection

J L Fahey  1
Affiliations
Review

Cytokines, plasma immune activation markers, and clinically relevant surrogate markers in human immunodeficiency virus infection

J L Fahey. Clin Diagn Lab Immunol. 1998 Sep.
No abstract available

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Figures

FIG. 1
FIG. 1
Schematic representation of some of the significant cytokine-mediated interactions between T cells and macrophages (Mφ) during HIV infection.
FIG. 2
FIG. 2
POP for occurrence of AIDS. This graphic method allows ready comprehension and comparison of several surrogate markers. Calculations are based on survival analysis regression methods with Gaussian error distribution, as described in detail in reference . Lower values are better; a perfect predictor would be one that had zero deviation and could predict future occurrence of AIDS to a precise day. This would have a scale value of zero. (A) Illustrative diagram of three hypothetical surrogate markers, X, Y, and Z. In this example, assay Y is not as good as X but is better than Z. (B) Graphic presentation of several surrogate markers. A group of 659 seropositive men with mean CD4 T-cell levels of 514/mm3 were evaluated for prediction of AIDS occurrence within 3 years (25). SP, prognostic precision for the study population as a whole without surrogate markers; T, plasma sTNF-α–RII levels; 4, CD4 T-cell levels; H, plasma HIV concentration; C1, combined value for CD4 T cells plus HIV load; C2, combined value for CD4 T cells plus sTNF-α–RII.
See this image and copyright information in PMC

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