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. 1998 Jul;6(7):1089-101.
doi: 10.1016/s0968-0896(98)00069-8.

Novel dithiocarbamate carbapenems with anti-MRSA activity

N Ohtake  1 , H Imamura, H Jona, H Kiyonaga, A Shimizu, M Moriya, H Sato, M Nakano, R Ushijima, S Nakagawa
Affiliations

Novel dithiocarbamate carbapenems with anti-MRSA activity

N Ohtake et al. Bioorg Med Chem. 1998 Jul.

Abstract

A new series of 1beta-methyl carbapenems, in which a disubstituted-aminothiocarbonylthio moiety was attached to the C-2 position of the carbapenem nucleus, were prepared and evaluated for anti-MRSA activity. These derivatives showed good in vitro antibacterial activity against high-level MRSA, and the finding of good affinity for PBP-2' supported these results. Some of the compounds having favorable protein-binding affinity showed excellent in vivo anti-MRSA activity.

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