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. 1998 Sep 11;281(5383):1690-3.
doi: 10.1126/science.281.5383.1690.

Prevention of cardiac hypertrophy in mice by calcineurin inhibition

M A Sussman  1 , H W Lim, N Gude, T Taigen, E N Olson, J Robbins, M C Colbert, A Gualberto, D F Wieczorek, J D Molkentin
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Prevention of cardiac hypertrophy in mice by calcineurin inhibition

M A Sussman et al. Science. .

Abstract

Hypertrophic cardiomyopathy (HCM) is an inherited form of heart disease that affects 1 in 500 individuals. Here it is shown that calcineurin, a calcium-regulated phosphatase, plays a critical role in the pathogenesis of HCM. Administration of the calcineurin inhibitors cyclosporin and FK506 prevented disease in mice that were genetically predisposed to develop HCM as a result of aberrant expression of tropomodulin, myosin light chain-2, or fetal beta-tropomyosin in the heart. Cyclosporin had a similar effect in a rat model of pressure-overload hypertrophy. These results suggest that calcineurin inhibitors merit investigation as potential therapeutics for certain forms of human heart disease.

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  • Science. 1998 Nov 6;282(5391):1007

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