doi: 10.1128/JVI.72.10.8362-8364.1998.
Mx1-based resistance to thogoto virus in A2G mice is bypassed in tick-mediated virus delivery
Affiliations
- PMID: 9733885
- PMCID: PMC110214
- DOI: 10.1128/JVI.72.10.8362-8364.1998
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Mx1-based resistance to thogoto virus in A2G mice is bypassed in tick-mediated virus delivery
J Virol.
1998 Oct.
Abstract
The interferon-induced mouse Mx1 protein has intrinsic antiviral activity against orthomyxoviruses, including Thogoto virus. Thus, Mx1(+) A2G mice are apparently resistant to infection following needle- or tick-borne virus challenge. However, tick-borne challenge and, to a lesser degree, injection of virus mixed with tick salivary gland extract resulted in virus transmission to uninfected ticks feeding on the A2G mice. The data indicate that immunomodulatory components in tick saliva can overcome a natural antiviral mechanism.
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References
-
- Davies C R, Jones L D, Nuttall P A. Experimental studies on the transmission cycle of Thogoto virus, a candidate orthomyxovirus, in Rhipicephalus appendiculatus ticks. Am J Trop Med Hyg. 1986;35:1256–1262. - PubMed
-
- Hajnicka V, Fuchsberger N, Slovak M, Kocakova P, Labuda M, Nuttall P A. Tick salivary gland extracts promote virus growth in vitro. Parasitology. 1998;116:533–538. - PubMed
-
- Haller O, Acklin M, Staeheli P. Influenza virus resistance in wild mice: wild-type and mutant Mx alleles occur at comparable frequencies. J Interferon Res. 1987;7:647–656. - PubMed
-
- Jones L D, Davies C R, Steele G M, Nuttall P A. A novel mode of arbovirus transmission involving a nonviraemic host. Science. 1987;237:775–777. - PubMed
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