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. 1998 Oct;72(10):8362-4.
doi: 10.1128/JVI.72.10.8362-8364.1998.

Mx1-based resistance to thogoto virus in A2G mice is bypassed in tick-mediated virus delivery

J T Dessens  1 , P A Nuttall
Affiliations

Mx1-based resistance to thogoto virus in A2G mice is bypassed in tick-mediated virus delivery

J T Dessens et al. J Virol. 1998 Oct.

Abstract

The interferon-induced mouse Mx1 protein has intrinsic antiviral activity against orthomyxoviruses, including Thogoto virus. Thus, Mx1(+) A2G mice are apparently resistant to infection following needle- or tick-borne virus challenge. However, tick-borne challenge and, to a lesser degree, injection of virus mixed with tick salivary gland extract resulted in virus transmission to uninfected ticks feeding on the A2G mice. The data indicate that immunomodulatory components in tick saliva can overcome a natural antiviral mechanism.

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