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. 1998 Sep;153(3):985-90.
doi: 10.1016/S0002-9440(10)65640-4.

DNA copy number changes in development and progression in leiomyosarcomas of soft tissues

W El-Rifai  1 , M Sarlomo-Rikala, S Knuutila, M Miettinen
Affiliations

DNA copy number changes in development and progression in leiomyosarcomas of soft tissues

W El-Rifai et al. Am J Pathol. 1998 Sep.

Abstract

DNA copy number changes were investigated in 29 leiomyosarcomas by comparative genomic hybridization. The most frequent losses were detected in 10q (20 cases, 69%) and 13q (17 cases, 59%). The most frequent gains were detected in 17p (16 cases, 55%). The most frequent high-level amplifications were detected in 17p (7 cases, 24%) and 8q (6 cases, 21%). A total of 137 losses and 204 gains were detected. Small tumors (less than 5 cm in diameter) displayed fewer changes per sample (3 to 11; mean, 7) than the other tumors (4 to 22; mean, 13). There was an increase in the number of gains from small tumors (mean, 4) to very large tumors (>20 cm; mean, 10). However, the number of losses was similar in small, large, and very large tumors (mean, 4.5). Tumor size-related aberrations were observed. Gains in 16p were detected in all small tumors but were infrequent in large and very large tumors (27% and 11%, respectively). Similarly, gains and high-level amplifications in 17p were more common in small (80%) than in very large tumors (33%). Gains in 1q, 5p, 6q, and 8q were not seen in any of the small tumors but were detected in large and very large tumors. Gains in 6q and 8q occurred in 8 of 9 cases (89%) of very large tumors, 5 of them with a high-level amplification in 8q.

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Figures

Figure 1.
Figure 1.
Summary of DNA copy number gains and losses detected by CGH in LMS. Each bar represents one tumor sample. Gains are on the right side, losses on the left. Dotted lines represent small tumors, broken lines large tumors, and continuous lines very large tumors.
Figure 2.
Figure 2.
Comparative frequencies of common losses and gains detected in small, large, and very large LMS tumors.
See this image and copyright information in PMC

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