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. 1998 Sep:67:S149-51.
doi: 10.1046/j.1523-1755.1998.06730.x.

Chloride channels ClC-2 and ICln mRNA expression differs in renal epithelial ontogeny

S Huber  1 , G Braun, B Schröppel, M Horster
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Free article

Chloride channels ClC-2 and ICln mRNA expression differs in renal epithelial ontogeny

S Huber et al. Kidney Int Suppl. 1998 Sep.
Free article

Abstract

Development-dependent mRNA expression of the chloride channels ClC-2 and ICln was studied by quantitative reverse transcriptase-polymerase chain reaction in rat ureteric bud and cortical collecting duct primary monolayer cultures. Abundance of ClC-2 mRNA increased in ureteric bud cells between embryonic day 15 (E15) and E17, peaked at postnatal day 3 (P3), and was down-regulated at P7 when morphogenesis is complete, suggesting a specific embryonic function. Expression of ICln mRNA, in contrast, up-regulated continuously with development.

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