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. 1998 Sep;42(9):2452-5.
doi: 10.1128/AAC.42.9.2452.

In vitro activity of the new glycopeptide LY333328 against multiply resistant gram-positive clinical isolates

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In vitro activity of the new glycopeptide LY333328 against multiply resistant gram-positive clinical isolates

F García-Garrote et al. Antimicrob Agents Chemother. 1998 Sep.

Abstract

The in vitro activity of LY333328 was compared with those of vancomycin and teicoplanin against 425 gram-positive clinical isolates, including a variety of multiply resistant strains. LY333328 at </=4 microgram/ml inhibited all microorganisms tested, including methicillin- and teicoplanin-resistant staphylococci, glycopeptide-resistant enterococci, penicillin- and multiply resistant pneumococci, and viridans and beta-hemolytic streptococci.

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References

    1. Banerjee, S. N., T. G. Emori, D. H. Culver, R. Gayne, W. R. Jarvi, T. Horan, J. R. Edward, J. Tolson, T. Henderson, and W. J. Martone. 1991. Secular trends in nosocomial bloodstream infections in the United States, 1980–1989. National Nosocomial Infection Surveillance System. Am. J. Med. 91(Suppl. 3B):86S–89S. - PubMed
    1. Biavasco F, Vignaroli C, Lupidi R, Manso E, Facinelli B, Varaldo P E. In vitro antibacterial activity of LY333328, a new semisynthetic glycopeptide. Antimicrob Agents Chemother. 1997;41:2165–2172. - PMC - PubMed
    1. Centers for Disease Control and Prevention. Nosocomial enterococci resistant to vancomycin—United States, 1989–1993. Morbid Mortal Weekly Rep. 1993;42:597–599. - PubMed
    1. Fasola E, Spangler S K, Ednie L M, Jacobs M R, Bajaksouzian S, Appelbaum P C. Comparative activities of LY333328, a new glycopeptide, against penicillin-susceptible and -resistant pneumococci. Antimicrob Agents Chemother. 1996;40:2661–2663. - PMC - PubMed
    1. Hackbarth C J, Chambers H F. Methicillin-resistant staphylococci: detection methods and treatment of infections. Antimicrob Agents Chemother. 1989;33:995–999. - PMC - PubMed