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. 1998 Sep;42(9):2456-8.
doi: 10.1128/AAC.42.9.2456.

Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives

K P Holland  1 , H L Elford, V Bracchi, C G Annis, S M Schuster, D Chakrabarti
Affiliations

Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives

K P Holland et al. Antimicrob Agents Chemother. 1998 Sep.

Abstract

Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.

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References

    1. Carmichael J, Cantwell B M J, Mannix K A, Veale D, Elford H L, Blackie R, Kerr D J, Kaye S B, Harris A L. A phase I pharmacokinetic study of didox administered by 36 hr infusion. Br J Cancer. 1990;61:447–450. - PMC - PubMed
    1. Chakrabarti D, Schuster S M, Chakrabarti R. Cloning and characterization of subunit genes of ribonucleotide reductase, a cell-cycle-regulated enzyme, from Plasmodium falciparum. Proc Natl Acad Sci USA. 1993;90:12020–12024. - PMC - PubMed
    1. Desjardins R E, Canfield C J, Haynes J D, Chulay J D. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Agents Chemother. 1979;16:710–718. - PMC - PubMed
    1. Elford H L, Elford R M, Wampler G L, van’t Riet B. New cancer chemotherapeutic agents that inhibit ribonucleotide reductase. In: Bardos T, Kalman T, editors. New approaches to the design of antineoplastic agents. New York, N.Y: Elsevier Science; 1982.
    1. Elford H L, Freese M, Passamani E, Morris H P. Ribonucleotide reductase and cell proliferation. I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas. J Biol Chem. 1970;245:5228–5233. - PubMed

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