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Review
. 1998 Aug;2(4):441-52.
doi: 10.1016/s1367-5931(98)80119-1.

Peptidomimetic design

A S Ripka  1 , D H Rich
Affiliations
Review

Peptidomimetic design

A S Ripka et al. Curr Opin Chem Biol. 1998 Aug.

Abstract

Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus protease, thrombin, HIV protease, Ras farnesyltransferase, the RGD motif, Factor Xa and various aspartic proteases have been discovered.

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