Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1998 Aug;2(4):453-7.
doi: 10.1016/s1367-5931(98)80120-8.

Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents

K C Lin  1 , A C Castro
Affiliations
Review

Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents

K C Lin et al. Curr Opin Chem Biol. 1998 Aug.

Abstract

In recent years antagonists of very late antigen-4 (VLA4, also known as integrin alpha(4) beta(1)) have shown great promise in treating inflammatory disorders in a number of animal models. The most advanced in this endeavor is a humanized anti-alpha(4) antibody, Antegren, which is in phase II clinical trials for multiple sclerosis. The first reported small-molecule VLA4 antagonist to advance into clinical trials is currently in phase I as an aerosol for treating asthma. A number of peptides, cyclic peptides and peptidomimetics have been disclosed and are in preliminary stages of development.

PubMed Disclaimer

MeSH terms

LinkOut - more resources