Review
doi: 10.1016/s0969-2126(98)00096-3.
HIV gp120: double lock strategy foils host defences
Affiliations
- PMID: 9739096
- DOI: 10.1016/s0969-2126(98)00096-3
Item in Clipboard
Review
HIV gp120: double lock strategy foils host defences
Structure.
.
Free article
Abstract
The recent determination of the structure of a complex formed between the HIV-1 glycoprotein gp120, CD4 and an antibody fragment has revealed new mechanisms for viral evasion of the immune response and shed light on how the virus enters target cells. The results of this work, together with related biochemical studies, may assist in the future design of therapeutic strategies against HIV-1 infection.
Similar articles
-
The antigenic structure of the HIV gp120 envelope glycoprotein.Nature. 1998 Jun 18;393(6686):705-11. doi: 10.1038/31514. Nature. 1998. PMID: 9641684
-
Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity.Nat Struct Mol Biol. 2010 May;17(5):608-13. doi: 10.1038/nsmb.1796. Epub 2010 Mar 31. Nat Struct Mol Biol. 2010. PMID: 20357769 Free PMC article.
-
HIV: conformational camouflage.Nature. 2002 Dec 12;420(6916):623-4. doi: 10.1038/420623a. Nature. 2002. PMID: 12478278 No abstract available.
-
CD4-induced epitopes in the HIV envelope glycoprotein, gp120.Curr HIV Res. 2007 Nov;5(6):561-71. doi: 10.2174/157016207782418560. Curr HIV Res. 2007. PMID: 18045112 Review.
-
HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors.Biochim Biophys Acta. 2003 Jul 11;1614(1):51-61. doi: 10.1016/s0005-2736(03)00162-7. Biochim Biophys Acta. 2003. PMID: 12873765 Review.
Cited by
-
Insight derived from molecular dynamics simulations into molecular motions, thermodynamics and kinetics of HIV-1 gp120.PLoS One. 2014 Aug 8;9(8):e104714. doi: 10.1371/journal.pone.0104714. eCollection 2014. PLoS One. 2014. PMID: 25105502 Free PMC article.
-
HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC.PLoS Pathog. 2009 May;5(5):e1000414. doi: 10.1371/journal.ppat.1000414. Epub 2009 May 8. PLoS Pathog. 2009. PMID: 19424423 Free PMC article.
-
HIV-1-envelope trimer transitions from prefusion-closed to CD4-bound-open conformations through an occluded-intermediate state.bioRxiv [Preprint]. 2024 Jul 17:2024.07.15.603531. doi: 10.1101/2024.07.15.603531. bioRxiv. 2024. Update in: Comput Struct Biotechnol J. 2024 Nov 12;23:4192-4204. doi: 10.1016/j.csbj.2024.11.020. PMID: 39071380 Free PMC article. Updated. Preprint.
-
The natural host range shift and subsequent evolution of canine parvovirus resulted from virus-specific binding to the canine transferrin receptor.J Virol. 2003 Feb;77(3):1718-26. doi: 10.1128/jvi.77.3.1718-1726.2003. J Virol. 2003. PMID: 12525605 Free PMC article.
-
Sequential antigen panning for selection of broadly cross-reactive HIV-1-neutralizing human monoclonal antibodies.Methods Mol Biol. 2009;562:143-54. doi: 10.1007/978-1-60327-302-2_11. Methods Mol Biol. 2009. PMID: 19554293 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
