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. 1976 Feb;3(1):169-75.
doi: 10.1111/j.1365-2125.1976.tb00585.x.

Renal function, protein binding and pharmacological response to diazoxide

R M Pearson, A M Breckenridge

Renal function, protein binding and pharmacological response to diazoxide

R M Pearson et al. Br J Clin Pharmacol. 1976 Feb.

Abstract

1 The effect of rapid (10s) injections of diazoxide was studied in ten hypertensive patients with varying degrees of impairment of renal function. 2 There was a significant correlation between the patient's plasma urea concentration and reduction in mean arterial blood pressure. Diazoxide was also shown to be less highly protein bound in patients with renal failure. 3 It is suggested that the explanation for the increased hypotensive effect of diazoxide observed in patients with reduced renal function is related to higher unbound drug concentrations.

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References

    1. Klin Wochenschr. 1964 Jan 15;42:103-8 - PubMed
    1. J Pharm Sci. 1967 Jul;56(7):912-4 - PubMed
    1. Clin Chim Acta. 1964 Oct;10:381-4 - PubMed
    1. J Clin Invest. 1957 May;36(5):738-48 - PubMed
    1. N Engl J Med. 1971 Jul 29;285(5):264-7 - PubMed

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