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Comparative Study
. 1976 Oct;3(5):903-6.
doi: 10.1111/j.1365-2125.1976.tb00645.x.

A radioimmunoassay method for prednisolone: comparison with the competitive protein binding method

J Chakraborty, J English, V Marks, M C Dumasia, D J Chapman
Comparative Study

A radioimmunoassay method for prednisolone: comparison with the competitive protein binding method

J Chakraborty et al. Br J Clin Pharmacol. 1976 Oct.

Abstract

Cross reactivity of prednisolone with an antiserum raised against dexamethasone-21-hemisuccinate conjugated with bovine serum albumin was utilized to develop a radioimmunoassay for prednisolone in unextracted plasma. The results are in good agreement with those obtained with a standard competitive protein binding method employing prior extraction and separation of the synthetic from endogenous steroids.

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References

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