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Comparative Study
. 1976 Oct;3(5):925-8.
doi: 10.1111/j.1365-2125.1976.tb00648.x.

The ralationship between changes in 5-HT induced platelet aggregation and clinical state in patients treated with fluphenazine

M W Orr, D J Boullin
Comparative Study

The ralationship between changes in 5-HT induced platelet aggregation and clinical state in patients treated with fluphenazine

M W Orr et al. Br J Clin Pharmacol. 1976 Oct.

Abstract

Platelet aggregation responses to 5-HT and adenosine diphosphate were examined in a population of eighteen patients treated with fluphenazine decanoate for longer than one year. 5-HT induced aggregation was enhanced in ten subjects. This enhancement was similar to that previously described in patients receiving chlorpromazine. Patients who showed enhanced 5-HT induced aggregation showed less rateable psychopathology and less extrapyramidal side-effects than patients who did not show enhancement. These findings suggest that platelet aggregation responses could be used to identify patients who could be safely withdrawn from long-term neuroleptic therapy.

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References

    1. Br J Clin Pharmacol. 1975 Feb;2(1):29-35 - PubMed
    1. Br J Pharmacol. 1975 Jan;53(1):121-5 - PubMed
    1. Br J Pharmacol. 1975 Dec;55(4):555-7 - PubMed
    1. J Physiol. 1972 Mar;221(2):415-26 - PubMed

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