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Comparative Study
. 1998 Sep;7(5):364-9.

Opioid withdrawal in neonates after continuous infusions of morphine or fentanyl during extracorporeal membrane oxygenation

L S Franck  1 , J Vilardi, D Durand, R Powers
Affiliations
  • PMID: 9740886
Comparative Study

Opioid withdrawal in neonates after continuous infusions of morphine or fentanyl during extracorporeal membrane oxygenation

L S Franck et al. Am J Crit Care. 1998 Sep.

Abstract

Background: Complications of opioid analgesia include tolerance and withdrawal.

Objectives: To determine the effects of morphine and fentanyl on the prevalence of withdrawal after extracorporeal membrane oxygenation.

Methods: Two groups of neonates were compared during and after extracorporeal membrane oxygenation: a prospective group receiving a continuous infusion of morphine for analgesia and sedation and a retrospective group who had received a continuous infusion of fentanyl.

Results: Neonates receiving morphine required significantly less supplemental analgesia (P < .001) than did neonates who had received fentanyl and had a significantly lower prevalence of withdrawal after the therapy (P = .01). Neonates receiving morphine were discharged from the hospital a mean of 9.6 days sooner (P = .01) than neonates who had received fentanyl.

Conclusions: Morphine may offer marked advantages over fentanyl for providing continuous analgesia and sedation in neonates.

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