Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Apr 30;53(1-3):93-103.
doi: 10.1016/s0168-3659(97)00242-3.

Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives

G D Prestwich  1 , D M Marecak, J F Marecek, K P Vercruysse, M R Ziebell
Affiliations

Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives

G D Prestwich et al. J Control Release. .

Abstract

Controlled modification of the carboxylic acid moieties of hyaluronic acid with mono- and polyfunctional hydrazides leads to biochemical probes, biopolymers with altered physical and chemical properties, tethered drugs for controlled release, and crosslinked hydrogels as biocompatible scaffoldings for tissue engineering. Methods for polyhydrazide synthesis, for prodrug preparation, for hydrogel crosslinking, and for monitoring biodegradation are described.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources