Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Sep;78(6):757-9.
doi: 10.1038/bjc.1998.573.

P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma

S D Shnyder  1 , A J Hayes, J Pringle, C W Archer
Affiliations
Free PMC article

P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma

S D Shnyder et al. Br J Cancer. 1998 Sep.
Free PMC article

Abstract

The expression of the drug resistance (DR) mediators P-glycoprotein (P-gp) and the metallothioneins (MT) was assessed immunohistochemically in biopsy material from patients with high-grade malignant osteosarcoma (OS). No significant difference was found in survival rate between expressors of both P-gp and MT and non-expressors. Thus, it was concluded that lack of expression of these two drug resistance-related proteins does not appear to confer any advantage in terms of patient survival in osteosarcoma.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Biochim Biophys Acta. 1976 Nov 11;455(1):152-62 - PubMed
    1. Science. 1986 Feb 21;231(4740):854-6 - PubMed
    1. Cancer Res. 1987 Apr 15;47(8):2056-61 - PubMed
    1. Cancer Cells. 1990 Feb;2(2):35-43 - PubMed
    1. Diagn Mol Pathol. 1995 Mar;4(1):59-65 - PubMed

MeSH terms

Substances